Quick Facts

• Researchers reviewed 33 studies on workout supplements and found six ingredients with potential heart health benefits
• Creatine may protect the heart through antioxidant properties and energy generation support
• Pre-workout supplement market expected to reach $37.93 billion by 2035 as mainstream consumers adopt sports nutrition

Popular workout supplements may offer more than muscle gains. A new review of 33 studies published in April 2026 identified six common pre-workout ingredients that could support heart health alongside fitness performance.

The analysis examined creatine, beta-alanine, citrulline, and three other supplements. Researchers found these ingredients show promise for cardiovascular benefits through mechanisms like antioxidant protection and improved circulation.

Creatine Shows Antioxidant Protection

Creatine leads the list with its dual benefits. The supplement’s antioxidant capabilities and energy generation support may help protect the heart against oxidative stress, according to the review. Studies suggest creatine supplementation could shield cardiac muscle tissue from damage associated with heart attacks and heart failure.

Beta-alanine earned recognition for its indirect heart support through antioxidant effects. The supplement helps produce carnosine, which test-tube studies show can elevate nitric oxide production and potentially improve heart health.

Circulation Benefits From Citrulline

Citrulline demonstrated cardiovascular benefits through improved circulation and blood pressure reduction. The amino acid can address symptoms of poor circulation, making it valuable beyond workout performance enhancement.

The pre-workout supplement market reflects growing mainstream adoption. Approximately 28% of all dietary supplement users in the US now take sport-specific supplements, with lifestyle users accounting for 40% of the sports nutrition consumer base compared to elite athletes.

Medical Experts Urge Caution

Despite potential benefits, cardiologists emphasize limits. Dr. Dmitry Yaranov, a cardiologist, stated that supplements “should never replace lifestyle habits like diet, exercise, and smoking cessation.” He prescribes certain supplements alongside medications but maintains lifestyle changes as the foundation.

Safety concerns persist with high-caffeine formulations. Pre-workout supplements can raise risks of hypertension, cardiac arrhythmias, and potentially heart attacks in individuals with severe coronary disease. The FDA does not regulate supplement safety, effectiveness, or labeling.

The effectiveness for cardiovascular disease prevention remains unclear despite broad popularity. Researchers called for more randomized prospective trials to establish proper dosing, risks, and benefits for heart disease patients.

The global pre-workout supplement market reached $20.98 billion in 2025 and projects growth to $37.93 billion by 2035. This expansion reflects increasing health consciousness and growing interest in sports nutrition across all age groups.

Read more: These 6 Popular Workout Supplements Can Also Support Your Heart Health